Delta Air Lines flight DL 5646: Multiple routes

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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 09:00 New York John F. Kennedy (JFK) 4 11:24 Charleston (CHS)
DL 5646 Non-stop Embraer EMB 175 (E75) 2:24 Valid until 2026-01-04
Mon-Fri,Sun 14:07 New York LaGuardia (LGA) C 16:29 Indianapolis (IND)
DL 5646 Non-stop Embraer EMB 175 (E75) 2:22 Effective 2026-03-08 through 2026-04-12
Mon-Fri,Sun 14:29 New York LaGuardia (LGA) C 16:53 Indianapolis (IND)
DL 5646 Non-stop Embraer EMB 175 (E75) 2:24 Effective 2026-04-13 through 2026-10-05
Sat 14:29 New York LaGuardia (LGA) C 16:53 Indianapolis (IND)
DL 5646 Non-stop Embraer EMB 175 (E75) 2:24 Effective 2026-08-15 through 2026-10-03
Daily 14:29 New York LaGuardia (LGA) C 16:52 Indianapolis (IND)
DL 5646 Non-stop Embraer EMB 175 (E75) 2:23 Effective from 2026-10-06
Sat 16:10 New York LaGuardia (LGA) C 18:39 Indianapolis (IND)
DL 5646 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:29 Effective 2026-01-10 through 2026-02-07
Sat 16:15 New York LaGuardia (LGA) C 18:42 Indianapolis (IND)
DL 5646 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:27 Effective 2026-02-28 through 2026-03-07
Sat 16:15 New York LaGuardia (LGA) C 18:40 Indianapolis (IND)
DL 5646 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:25 Effective 2026-03-14 through 2026-04-11
Sat 16:15 New York LaGuardia (LGA) C 18:39 Indianapolis (IND)
DL 5646 Non-stop Embraer EMB 175 (E75) 2:24 Effective 2026-04-18 through 2026-08-08
Sat 16:30 New York LaGuardia (LGA) C 18:58 Indianapolis (IND)
DL 5646 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:28 Effective 2026-02-14 through 2026-02-21
Mon-Fri,Sun 17:45 Indianapolis (IND) 19:56 New York LaGuardia (LGA) C
DL 5646 Non-stop Embraer EMB 175 (E75) 2:11 Effective 2026-04-13 through 2026-10-05
Mon-Fri,Sun 17:45 Indianapolis (IND) 19:55 New York LaGuardia (LGA) C
DL 5646 Non-stop Embraer EMB 175 (E75) 2:10 Effective from 2026-10-06
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This flight number is listed as serving the following routes:


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Delta Air Lines flight DL 5646: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Delta Air Lines DL5646
09:00
New York John F. Kennedy (JFK) 4

11:24
Charleston (CHS)
Valid until 2026-01-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:24, non-stop
Embraer EMB 175 (E75)
Direct Flights:
Delta Air Lines DL5646
14:07
New York LaGuardia (LGA) C

16:29
Indianapolis (IND)
Effective 2026-03-08 through 2026-04-12
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:22, non-stop
Embraer EMB 175 (E75)
Direct Flights:
Delta Air Lines DL5646
14:29
New York LaGuardia (LGA) C

16:53
Indianapolis (IND)
Effective 2026-04-13 through 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:24, non-stop
Embraer EMB 175 (E75)
Direct Flights:
Delta Air Lines DL5646
14:29
New York LaGuardia (LGA) C

16:53
Indianapolis (IND)
Effective 2026-08-15 through 2026-10-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:24, non-stop
Embraer EMB 175 (E75)
Direct Flights:
Delta Air Lines DL5646
14:29
New York LaGuardia (LGA) C

16:52
Indianapolis (IND)
Effective from 2026-10-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:23, non-stop
Embraer EMB 175 (E75)
Direct Flights:
Delta Air Lines DL5646
16:10
New York LaGuardia (LGA) C

18:39
Indianapolis (IND)
Effective 2026-01-10 through 2026-02-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:29, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
Delta Air Lines DL5646
16:15
New York LaGuardia (LGA) C

18:42
Indianapolis (IND)
Effective 2026-02-28 through 2026-03-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:27, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
Delta Air Lines DL5646
16:15
New York LaGuardia (LGA) C

18:40
Indianapolis (IND)
Effective 2026-03-14 through 2026-04-11
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:25, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
Delta Air Lines DL5646
16:15
New York LaGuardia (LGA) C

18:39
Indianapolis (IND)
Effective 2026-04-18 through 2026-08-08
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:24, non-stop
Embraer EMB 175 (E75)
Direct Flights:
Delta Air Lines DL5646
16:30
New York LaGuardia (LGA) C

18:58
Indianapolis (IND)
Effective 2026-02-14 through 2026-02-21
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:28, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
Delta Air Lines DL5646
17:45
Indianapolis (IND)

19:56
New York LaGuardia (LGA) C
Effective 2026-04-13 through 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:11, non-stop
Embraer EMB 175 (E75)
Direct Flights:
Delta Air Lines DL5646
17:45
Indianapolis (IND)

19:55
New York LaGuardia (LGA) C
Effective from 2026-10-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:10, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • New York John F. Kennedy (JFK) - Charleston (CHS)
  • New York LaGuardia (LGA) - Indianapolis (IND)
All Delta Air Lines flights
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