American Airlines
flight
AA 5381:
Multiple routes
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FLIGHT SCHEDULE
Direct Flights:
American Airlines AA5381
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:04, non-stop
Canadair CRJ 900 (CR9)
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5381
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:02, non-stop
Canadair CRJ 900 (CR9)
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5381
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 0:59, non-stop
Canadair CRJ 900 (CR9)
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5381
Effective 2026-01-07 through 2026-02-09
Mon
Tue
-
-
Wed
Thu
Fri
Sat
-
-
Sun
Duration: 2:02, non-stop
Canadair CRJ 900 (CR9)
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5381
Effective 2026-01-07 through 2026-02-09
Mon
Tue
-
-
Wed
Thu
Fri
Sat
-
-
Sun
Duration: 1:49, non-stop
Canadair CRJ 900 (CR9)
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5381
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:05, non-stop
Canadair CRJ 900 (CR9)
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5381
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:39, non-stop
Canadair CRJ 900 (CR9)
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5381
Valid until 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
-
-
Sun
Duration: 1:21, non-stop
Canadair CRJ 700 (CR7)
Canadair CRJ 700 (CR7)
Direct Flights:
American Airlines AA5381
Valid until 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
-
-
Sun
Duration: 1:31, non-stop
Canadair CRJ 700 (CR7)
Canadair CRJ 700 (CR7)
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This flight number is listed as serving the following routes:
- Dayton (DAY) - Chicago O'Hare (ORD)
- Greenville/Spartanburg (GSP) - Charlotte (CLT)
- Oklahoma City (OKC) - Charlotte (CLT)
- Philadelphia (PHL) - Greenville/Spartanburg (GSP)