American Airlines flight AA 5181: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 10:07 Chicago O'Hare (ORD) 3 12:46 Knoxville (TYS)
AA 5181 Non-stop Canadair CRJ 700 (CR7) 1:39 Effective 2026-01-06 through 2026-01-17
Daily 10:07 Chicago O'Hare (ORD) 3 12:46 Knoxville (TYS)
AA 5181 Non-stop Canadair CRJ 700 (CR7) 1:39 Effective 2026-01-19 through 2026-02-11
Daily 12:15 Ronald Reagan Washington (DCA) 2 14:04 Indianapolis (IND)
AA 5181 Non-stop Canadair CRJ 700 (CR7) 1:49 Effective 2026-08-05 through 2026-09-08
Daily 14:34 Indianapolis (IND) 16:19 Ronald Reagan Washington (DCA) 2
AA 5181 Non-stop Canadair CRJ 700 (CR7) 1:45 Effective 2026-08-05 through 2026-09-08
Daily 16:20 Charlotte (CLT) 17:38 Charleston (CRW)
AA 5181 Non-stop Canadair CRJ 700 (CR7) 1:18 Effective 2026-04-07 through 2026-05-20
Daily 16:35 Dallas Fort Worth (DFW) 18:41 Nashville (BNA)
AA 5181 Non-stop Canadair CRJ 900 (CR9) 2:06 Effective from 2026-10-05
Tue,Wed 17:25 Charlotte (CLT) 18:45 Savannah (SAV)
AA 5181 Non-stop Canadair CRJ 900 (CR9) 1:20 Effective 2026-02-17 through 2026-03-04
Daily 18:13 Charleston (CRW) 19:40 Charlotte (CLT)
AA 5181 Non-stop Canadair CRJ 700 (CR7) 1:27 Effective 2026-04-07 through 2026-05-20
Mon,Thu,Fri,Sun 18:20 Charlotte (CLT) 19:38 Savannah (SAV)
AA 5181 Non-stop Canadair CRJ 900 (CR9) 1:18 Effective 2026-02-12 through 2026-03-06
Mon,Tue,Thu-Sun 18:23 Charlotte (CLT) 19:42 Savannah (SAV)
AA 5181 Non-stop Canadair CRJ 700 (CR7) 1:19 Valid until 2026-01-05
Sat 18:23 Charlotte (CLT) 19:41 Savannah (SAV)
AA 5181 Non-stop Canadair CRJ 900 (CR9) 1:18 Effective 2026-02-14 through 2026-03-07
Daily 18:30 Chicago O'Hare (ORD) 3 21:23 Greenville/Spartanburg (GSP)
AA 5181 Non-stop Canadair CRJ 700 (CR7) 1:53 Effective 2026-05-21 through 2026-07-01
Daily 18:30 Chicago O'Hare (ORD) 3 21:31 Greenville/Spartanburg (GSP)
AA 5181 Non-stop Canadair CRJ 700 (CR7) 2:01 Effective 2026-07-02 through 2026-08-04
Mon,Wed-Sun 19:07 Charlotte (CLT) 20:02 Greenville/Spartanburg (GSP)
AA 5181 Non-stop Canadair CRJ 900 (CR9) 0:55 Effective 2026-03-08 through 2026-04-06
Daily 19:41 Nashville (BNA) 21:50 Dallas Fort Worth (DFW)
AA 5181 Non-stop Canadair CRJ 900 (CR9) 2:09 Effective from 2026-10-05
Tue 19:46 Charlotte (CLT) 20:41 Greenville/Spartanburg (GSP)
AA 5181 Non-stop Canadair CRJ 900 (CR9) 0:55 Effective 2026-03-10 through 2026-03-31
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This flight number is listed as serving the following routes:
American Airlines flight AA 5181: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:

American Airlines AA5181
Effective 2026-01-06 through 2026-01-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:39, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5181
Effective 2026-01-19 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:39, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5181
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:49, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5181
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:45, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5181
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:18, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5181
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:06, non-stop
Canadair CRJ 900 (CR9)

Direct Flights:

American Airlines AA5181
Effective 2026-02-17 through 2026-03-04
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 1:20, non-stop
Canadair CRJ 900 (CR9)

Direct Flights:

American Airlines AA5181
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:27, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5181
Effective 2026-02-12 through 2026-03-06
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
Duration: 1:18, non-stop
Canadair CRJ 900 (CR9)

Direct Flights:

American Airlines AA5181
Valid until 2026-01-05
Mon
Tue
Wed
-
Thu
Fri
Sat
Sun
Duration: 1:19, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5181
Effective 2026-02-14 through 2026-03-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:18, non-stop
Canadair CRJ 900 (CR9)

Direct Flights:

American Airlines AA5181
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:53, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5181
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:01, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5181
Effective 2026-03-08 through 2026-04-06
Mon
Tue
-
Wed
Thu
Fri
Sat
Sun
Duration: 0:55, non-stop
Canadair CRJ 900 (CR9)

Direct Flights:

American Airlines AA5181
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:09, non-stop
Canadair CRJ 900 (CR9)

Direct Flights:

American Airlines AA5181
Effective 2026-03-10 through 2026-03-31
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 0:55, non-stop
Canadair CRJ 900 (CR9)
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This flight number is listed as serving the following routes:
  • Charleston (CRW) - Charlotte (CLT)
  • Charlotte (CLT) - Greenville/Spartanburg (GSP)
  • Charlotte (CLT) - Savannah (SAV)
  • Chicago O'Hare (ORD) - Greenville/Spartanburg (GSP)
  • Chicago O'Hare (ORD) - Knoxville (TYS)
  • Dallas Fort Worth (DFW) - Nashville (BNA)
  • Ronald Reagan Washington (DCA) - Indianapolis (IND)