American Airlines flight AA 4780: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Sat 05:00 Syracuse (SYR) 08:50 Miami (MIA)
AA 4780 Non-stop Embraer EMB 175 (E75) 3:50 Effective 2026-01-10 through 2026-02-07
Sat 05:00 Syracuse (SYR) 08:42 Miami (MIA)
AA 4780 Non-stop Embraer EMB 175 (E75) 3:42 Effective 2026-02-14 through 2026-03-07
Sat 05:00 Syracuse (SYR) 08:33 Miami (MIA)
AA 4780 Non-stop Embraer EMB 175 (E75) 3:33 Effective 2026-03-14 through 2026-04-04
Sun 07:46 Louisville (SDF) 08:26 Chicago O'Hare (ORD) 3
AA 4780 Non-stop Embraer EMB 175 (E75) 1:40 Operates only on 2026-01-04
Sat 08:00 Louisville (SDF) 08:40 Chicago O'Hare (ORD) 3
AA 4780 Non-stop Embraer EMB 175 (E75) 1:40 Operates only on 2026-01-03
Mon-Fri 08:05 Louisville (SDF) 08:45 Chicago O'Hare (ORD) 3
AA 4780 Non-stop Embraer EMB 175 (E75) 1:40 Valid until 2026-01-05
Daily 16:00 Chicago O'Hare (ORD) 3 17:39 Minneapolis/Saint Paul (MSP) 1
AA 4780 Non-stop Embraer EMB 175 (E75) 1:39 Effective 2026-08-05 through 2026-09-08
Daily 18:09 Minneapolis/Saint Paul (MSP) 1 19:48 Chicago O'Hare (ORD) 3
AA 4780 Non-stop Embraer EMB 175 (E75) 1:39 Effective 2026-08-05 through 2026-09-08
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4780: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4780
05:00
Syracuse (SYR)

08:50
Miami (MIA)
Effective 2026-01-10 through 2026-02-07
Mon
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Tue
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Wed
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Thu
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Fri
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Sat
Sun
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Duration: 3:50, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4780
05:00
Syracuse (SYR)

08:42
Miami (MIA)
Effective 2026-02-14 through 2026-03-07
Mon
-
Tue
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Wed
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Thu
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Fri
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Sat
Sun
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Duration: 3:42, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4780
05:00
Syracuse (SYR)

08:33
Miami (MIA)
Effective 2026-03-14 through 2026-04-04
Mon
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Tue
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Wed
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Thu
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Fri
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Sat
Sun
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Duration: 3:33, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4780
07:46
Louisville (SDF)

08:26
Chicago O'Hare (ORD) 3
Operates only on 2026-01-04
Mon
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Tue
-
Wed
-
Thu
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Fri
-
Sat
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Sun
Duration: 1:40, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4780
08:00
Louisville (SDF)

08:40
Chicago O'Hare (ORD) 3
Operates only on 2026-01-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
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Duration: 1:40, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4780
08:05
Louisville (SDF)

08:45
Chicago O'Hare (ORD) 3
Valid until 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 1:40, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4780
16:00
Chicago O'Hare (ORD) 3

17:39
Minneapolis/Saint Paul (MSP) 1
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:39, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4780
18:09
Minneapolis/Saint Paul (MSP) 1

19:48
Chicago O'Hare (ORD) 3
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:39, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Louisville (SDF) - Chicago O'Hare (ORD)
  • Minneapolis/Saint Paul (MSP) - Chicago O'Hare (ORD)
  • Syracuse (SYR) - Miami (MIA)
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