American Airlines flight AA 4645: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Thu 06:00 Buffalo (BUF) 07:27 Chicago O'Hare (ORD) 3
AA 4645 Non-stop Embraer EMB 175 (E75) 2:27 Operates only on 2026-02-12
Daily 08:20 Ronald Reagan Washington (DCA) 2 10:07 Saint Louis (STL) 1
AA 4645 Non-stop Embraer EMB 175 (E75) 2:47 Effective from 2026-10-05
Daily 10:54 Saint Louis (STL) 1 13:59 Ronald Reagan Washington (DCA) 2
AA 4645 Non-stop Embraer EMB 175 (E75) 2:05 Effective from 2026-10-05
Sat 18:31 Ronald Reagan Washington (DCA) 2 20:13 Boston Logan (BOS) B
AA 4645 Non-stop Embraer EMB 175 (E75) 1:42 Effective 2026-01-10 through 2026-02-07
Sat 18:59 Ronald Reagan Washington (DCA) 2 20:33 Boston Logan (BOS) B
AA 4645 Non-stop Embraer EMB 175 (E75) 1:34 Valid until 2026-01-03
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4645: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4645
06:00
Buffalo (BUF)

07:27
Chicago O'Hare (ORD) 3
Operates only on 2026-02-12
Mon
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Tue
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Wed
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Thu
Fri
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Sat
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Sun
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Duration: 2:27, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4645
08:20
Ronald Reagan Washington (DCA) 2

10:07
Saint Louis (STL) 1
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:47, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4645
10:54
Saint Louis (STL) 1

13:59
Ronald Reagan Washington (DCA) 2
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:05, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4645
18:31
Ronald Reagan Washington (DCA) 2

20:13
Boston Logan (BOS) B
Effective 2026-01-10 through 2026-02-07
Mon
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Tue
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Wed
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Thu
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Fri
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Sat
Sun
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Duration: 1:42, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4645
18:59
Ronald Reagan Washington (DCA) 2

20:33
Boston Logan (BOS) B
Valid until 2026-01-03
Mon
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Tue
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Wed
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Thu
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Fri
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Sat
Sun
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Duration: 1:34, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Buffalo (BUF) - Chicago O'Hare (ORD)
  • Ronald Reagan Washington (DCA) - Boston Logan (BOS)
  • Saint Louis (STL) - Ronald Reagan Washington (DCA)
All American Airlines flights
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