American Airlines flight AA 4452: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Mon-Fri 06:00 Ronald Reagan Washington (DCA) 2 08:14 Atlanta (ATL) N
AA 4452 Non-stop Embraer EMB 175 (E75) 2:14 Effective 2026-02-12 through 2026-03-06
Daily 07:23 Minneapolis/Saint Paul (MSP) 1 09:10 Chicago O'Hare (ORD) 3
AA 4452 Non-stop Embraer EMB 175 (E75) 1:47 Effective 2026-04-07 through 2026-05-20
Mon-Fri,Sun 08:40 Philadelphia (PHL) 12:17 Key West (EYW)
AA 4452 Non-stop Embraer EMB 175 (E75) 3:37 Effective 2026-03-08 through 2026-04-06
Sat 08:42 Philadelphia (PHL) 12:19 Key West (EYW)
AA 4452 Non-stop Embraer EMB 175 (E75) 3:37 Effective 2026-03-14 through 2026-04-04
Mon-Fri 08:44 Atlanta (ATL) N 10:44 Ronald Reagan Washington (DCA) 2
AA 4452 Non-stop Embraer EMB 175 (E75) 2:00 Effective 2026-02-12 through 2026-03-06
Sat 09:55 Miami (MIA) 11:05 Key West (EYW)
AA 4452 Non-stop Embraer EMB 175 (E75) 1:10 Effective 2026-02-14 through 2026-03-07
Daily 11:41 Chicago O'Hare (ORD) 3 14:31 Knoxville (TYS)
AA 4452 Non-stop Embraer EMB 175 (E75) 1:50 Effective 2026-08-05 through 2026-09-08
Sat 11:47 Key West (EYW) 12:45 Miami (MIA)
AA 4452 Non-stop Embraer EMB 175 (E75) 0:58 Effective 2026-02-14 through 2026-03-07
Daily 12:49 Ronald Reagan Washington (DCA) 2 14:14 Providence (PVD)
AA 4452 Non-stop Embraer EMB 175 (E75) 1:25 Effective 2026-09-09 through 2026-10-04
Daily 14:39 Chicago O'Hare (ORD) 3 16:29 Kansas City (MCI)
AA 4452 Non-stop Embraer EMB 175 (E75) 1:50 Valid until 2026-01-05
Daily 14:44 Providence (PVD) 16:29 Ronald Reagan Washington (DCA) 2
AA 4452 Non-stop Embraer EMB 175 (E75) 1:45 Effective 2026-09-09 through 2026-10-04
Daily 14:54 Ronald Reagan Washington (DCA) 2 16:44 Indianapolis (IND)
AA 4452 Non-stop Embraer EMB 175 (E75) 1:50 Effective 2026-07-02 through 2026-08-04
Daily 15:01 Knoxville (TYS) 16:09 Chicago O'Hare (ORD) 3
AA 4452 Non-stop Embraer EMB 175 (E75) 2:08 Effective 2026-08-05 through 2026-09-08
Daily 16:59 Kansas City (MCI) 18:49 Chicago O'Hare (ORD) 3
AA 4452 Non-stop Embraer EMB 175 (E75) 1:50 Valid until 2026-01-05
Daily 18:35 Philadelphia (PHL) 20:39 Detroit (DTW) E
AA 4452 Non-stop Embraer EMB 175 (E75) 2:04 Effective from 2026-10-05
Sat 19:00 New York John F. Kennedy (JFK) 8 21:09 Cleveland (CLE)
AA 4452 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:09 Effective 2026-01-10 through 2026-01-24
Sat 19:30 New York John F. Kennedy (JFK) 8 21:39 Cleveland (CLE)
AA 4452 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:09 Operates only on 2026-01-31
Daily 20:35 Indianapolis (IND) 22:20 Ronald Reagan Washington (DCA) 2
AA 4452 Non-stop Embraer EMB 175 (E75) 1:45 Effective 2026-07-02 through 2026-08-04
Daily 20:58 Ronald Reagan Washington (DCA) 2 22:00 Birmingham (BHM)
AA 4452 Non-stop Embraer EMB 175 (E75) 2:02 Effective 2026-05-21 through 2026-07-01
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4452: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4452
06:00
Ronald Reagan Washington (DCA) 2

08:14
Atlanta (ATL) N
Effective 2026-02-12 through 2026-03-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 2:14, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
07:23
Minneapolis/Saint Paul (MSP) 1

09:10
Chicago O'Hare (ORD) 3
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:47, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
08:40
Philadelphia (PHL)

12:17
Key West (EYW)
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 3:37, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
08:42
Philadelphia (PHL)

12:19
Key West (EYW)
Effective 2026-03-14 through 2026-04-04
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 3:37, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
08:44
Atlanta (ATL) N

10:44
Ronald Reagan Washington (DCA) 2
Effective 2026-02-12 through 2026-03-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 2:00, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
09:55
Miami (MIA)

11:05
Key West (EYW)
Effective 2026-02-14 through 2026-03-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:10, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
11:41
Chicago O'Hare (ORD) 3

14:31
Knoxville (TYS)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:50, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
11:47
Key West (EYW)

12:45
Miami (MIA)
Effective 2026-02-14 through 2026-03-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 0:58, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
12:49
Ronald Reagan Washington (DCA) 2

14:14
Providence (PVD)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:25, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
14:39
Chicago O'Hare (ORD) 3

16:29
Kansas City (MCI)
Valid until 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:50, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
14:44
Providence (PVD)

16:29
Ronald Reagan Washington (DCA) 2
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:45, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
14:54
Ronald Reagan Washington (DCA) 2

16:44
Indianapolis (IND)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:50, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
15:01
Knoxville (TYS)

16:09
Chicago O'Hare (ORD) 3
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:08, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
16:59
Kansas City (MCI)

18:49
Chicago O'Hare (ORD) 3
Valid until 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:50, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
18:35
Philadelphia (PHL)

20:39
Detroit (DTW) E
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:04, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
19:00
New York John F. Kennedy (JFK) 8

21:09
Cleveland (CLE)
Effective 2026-01-10 through 2026-01-24
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:09, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4452
19:30
New York John F. Kennedy (JFK) 8

21:39
Cleveland (CLE)
Operates only on 2026-01-31
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:09, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4452
20:35
Indianapolis (IND)

22:20
Ronald Reagan Washington (DCA) 2
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:45, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4452
20:58
Ronald Reagan Washington (DCA) 2

22:00
Birmingham (BHM)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:02, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Atlanta (ATL) - Ronald Reagan Washington (DCA)
  • Kansas City (MCI) - Chicago O'Hare (ORD)
  • Key West (EYW) - Miami (MIA)
  • Knoxville (TYS) - Chicago O'Hare (ORD)
  • Minneapolis/Saint Paul (MSP) - Chicago O'Hare (ORD)
  • New York John F. Kennedy (JFK) - Cleveland (CLE)
  • Philadelphia (PHL) - Detroit (DTW)
  • Philadelphia (PHL) - Key West (EYW)
  • Providence (PVD) - Ronald Reagan Washington (DCA)
  • Ronald Reagan Washington (DCA) - Birmingham (BHM)
  • Ronald Reagan Washington (DCA) - Indianapolis (IND)
All American Airlines flights
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