American Airlines
flight
AA 4421:
Multiple routes
Ad mobi flat here (320x100px) 6074960173 M FlightWNum Top Flat
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4421
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:12, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-03-14 through 2026-04-04
Mon
-
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Tue
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Wed
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Thu
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Fri
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-
Sat
Sun
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Duration: 2:23, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:09, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Valid until 2026-01-03
Mon
-
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Tue
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Wed
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Thu
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Fri
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-
Sat
Sun
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-
Duration: 2:19, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:42, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Valid until 2026-01-01
Mon
-
-
Tue
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-
Wed
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-
Thu
Fri
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-
Sat
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-
Sun
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Duration: 2:48, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:52, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:38, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:37, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Valid until 2026-01-05
Mon
Tue
Wed
-
-
Thu
-
-
Fri
Sat
-
-
Sun
Duration: 2:50, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Valid until 2026-01-01
Mon
-
-
Tue
-
-
Wed
-
-
Thu
Fri
-
-
Sat
-
-
Sun
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-
Duration: 2:21, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:32, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:48, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-03-08 through 2026-04-05
Mon
-
-
Tue
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-
Wed
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-
Thu
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Fri
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-
Sat
-
-
Sun
Duration: 1:39, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-03-13 through 2026-04-03
Mon
-
-
Tue
-
-
Wed
-
-
Thu
-
-
Fri
Sat
-
-
Sun
-
-
Duration: 1:39, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-03-09 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
-
-
Sat
-
-
Sun
-
-
Duration: 1:39, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-02-12 through 2026-03-06
Mon
Tue
Wed
Thu
Fri
Sat
-
-
Sun
Duration: 1:38, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Valid until 2026-01-05
Mon
Tue
Wed
-
-
Thu
-
-
Fri
Sat
-
-
Sun
Duration: 2:21, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:44, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:34, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-03-08 through 2026-04-05
Mon
-
-
Tue
-
-
Wed
-
-
Thu
-
-
Fri
-
-
Sat
-
-
Sun
Duration: 1:30, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-03-13 through 2026-04-03
Mon
-
-
Tue
-
-
Wed
-
-
Thu
-
-
Fri
Sat
-
-
Sun
-
-
Duration: 1:30, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-03-09 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
-
-
Sat
-
-
Sun
-
-
Duration: 1:30, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-02-12 through 2026-03-06
Mon
Tue
Wed
Thu
Fri
Sat
-
-
Sun
Duration: 1:37, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-01-06 through 2026-01-16
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4421
Effective 2026-01-18 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
Embraer EMB 175 (E75)
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Parallax here
This flight number is listed as serving the following routes:
- Boston Logan (BOS) - Indianapolis (IND)
- Chicago O'Hare (ORD) - Memphis (MEM)
- Cleveland (CLE) - New York John F. Kennedy (JFK)
- Greensboro/High Point (GSO) - New York LaGuardia (LGA)
- John Glenn Columbus (CMH) - Ronald Reagan Washington (DCA)
- Oklahoma City (OKC) - Chicago O'Hare (ORD)
- Raleigh/Durham (RDU) - Nashville (BNA)
- Ronald Reagan Washington (DCA) - Des Moines (DSM)
- Saint Louis (STL) - Ronald Reagan Washington (DCA)