American Airlines flight AA 4221: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 08:20 Ronald Reagan Washington (DCA) 2 10:16 Pensacola (PNS)
AA 4221 Non-stop Embraer EMB 175 (E75) 2:56 Effective 2026-09-09 through 2026-10-04
Mon,Thu-Sun 08:54 Tulsa (TUL) 10:56 Chicago O'Hare (ORD) 3
AA 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:02 Effective 2026-02-13 through 2026-03-07
Daily 08:55 Tulsa (TUL) 10:59 Chicago O'Hare (ORD) 3
AA 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:04 Effective 2026-03-08 through 2026-04-06
Tue,Wed 09:04 Tulsa (TUL) 11:06 Chicago O'Hare (ORD) 3
AA 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:02 Effective 2026-02-17 through 2026-03-04
Daily 10:46 Pensacola (PNS) 13:59 Ronald Reagan Washington (DCA) 2
AA 4221 Non-stop Embraer EMB 175 (E75) 2:13 Effective 2026-09-09 through 2026-10-04
Daily 21:45 Miami (MIA) 22:54 Tampa (TPA)
AA 4221 Non-stop Embraer EMB 175 (E75) 1:09 Effective 2026-07-02 through 2026-08-04
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4221: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4221
08:20
Ronald Reagan Washington (DCA) 2

10:16
Pensacola (PNS)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:56, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4221
08:54
Tulsa (TUL)

10:56
Chicago O'Hare (ORD) 3
Effective 2026-02-13 through 2026-03-07
Mon
Tue
-
Wed
-
Thu
Fri
Sat
Sun
Duration: 2:02, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4221
08:55
Tulsa (TUL)

10:59
Chicago O'Hare (ORD) 3
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:04, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4221
09:04
Tulsa (TUL)

11:06
Chicago O'Hare (ORD) 3
Effective 2026-02-17 through 2026-03-04
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:02, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4221
10:46
Pensacola (PNS)

13:59
Ronald Reagan Washington (DCA) 2
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:13, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4221
21:45
Miami (MIA)

22:54
Tampa (TPA)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:09, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Miami (MIA) - Tampa (TPA)
  • Ronald Reagan Washington (DCA) - Pensacola (PNS)
  • Tulsa (TUL) - Chicago O'Hare (ORD)
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