Alaska Airlines flight AS 4221: Multiple routes

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FLIGHT SCHEDULE
Direct Codeshare Flights:
Tue-Sat 06:00 Austin (AUS) 08:47 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Boeing 737-800 (738) 2:47 Effective 2025-05-10 through 2025-05-17
Codeshare flight, operated by American Airlines.(AA 1064)
Daily 06:00 Austin (AUS) 08:47 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Boeing 737-800 (738) 2:47 Effective 2025-05-18 through 2025-06-04
Codeshare flight, operated by American Airlines.(AA 1064)
Thu 06:01 Austin (AUS) 08:45 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Airbus A319 (319) 2:44 Operates only on 2025-06-05
Codeshare flight, operated by American Airlines.(AA 1064)
Daily 06:01 Austin (AUS) 08:50 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Boeing 737-800 (738) 2:49 Effective 2025-06-06 through 2025-07-02
Codeshare flight, operated by American Airlines.(AA 1064)
Thu 06:01 Austin (AUS) 08:48 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Airbus A321 (321) 2:47 Operates only on 2025-07-03
Codeshare flight, operated by American Airlines.(AA 1064)
Daily 07:27 Albany (ALB) 09:10 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:43 Effective 2025-12-03 through 2025-12-17
Codeshare flight, operated by American Airlines.(AA 3361)
Sat 08:00 Chicago O'Hare (ORD) 3 10:06 Fort Wayne (FWA)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:06 Effective 2025-11-08 through 2025-11-15
Codeshare flight, operated by American Airlines.(AA 4905)
Thu-Sat 08:00 Chicago O'Hare (ORD) 3 10:06 Fort Wayne (FWA)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:06 Effective 2025-11-20 through 2025-11-22
Codeshare flight, operated by American Airlines.(AA 4905)
Daily 10:38 Chicago O'Hare (ORD) 3 12:55 Traverse City (TVC)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:17 Effective 2025-09-03 through 2025-10-05
Codeshare flight, operated by American Airlines.(AA 4948)
Mon-Fri,Sun 10:41 Asheville/Hendersonville (AVL) 12:13 Ronald Reagan Washington (DCA) 2
AS 4221 Non-stop Embraer EMB 175 (E75) 1:32 Valid until 2025-05-04
Codeshare flight, operated by American Airlines.(AA 4730)
Daily 11:27 Harrisburg (MDT) 12:43 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:16 Effective 2025-08-06 through 2025-09-02
Codeshare flight, operated by American Airlines.(AA 3442)
Mon-Fri,Sun 13:10 Chicago O'Hare (ORD) 3 16:10 Albany (ALB)
AS 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:00 Effective 2025-11-02 through 2025-11-19
Codeshare flight, operated by American Airlines.(AA 3414)
Mon-Fri,Sun 14:50 Dallas Fort Worth (DFW) E 16:06 Lubbock (LBB)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:16 Effective 2025-11-23 through 2025-11-28
Codeshare flight, operated by American Airlines.(AA 6342)
Sat 14:50 Chicago O'Hare (ORD) 3 17:49 Richmond (RIC)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:59 Operates only on 2025-11-29
Codeshare flight, operated by American Airlines.(AA 4896)
Mon,Tue,Sun 14:50 Chicago O'Hare (ORD) 3 16:50 Fargo (FAR)
AS 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:00 Effective 2025-11-30 through 2025-12-02
Codeshare flight, operated by American Airlines.(AA 3620)
Daily 16:16 Dayton (DAY) 17:55 Philadelphia (PHL) F
AS 4221 Non-stop Embraer ERJ 145 (ER4) 1:39 Effective 2025-10-06 through 2025-11-01
Codeshare flight, operated by American Airlines.(AA 5874)
Daily 17:00 Ronald Reagan Washington (DCA) 2 18:56 Louisville (SDF)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:56 Effective 2026-01-06 through 2026-02-11
Codeshare flight, operated by American Airlines.(AA 5189)
Mon-Fri,Sun 17:45 Dallas Fort Worth (DFW) 19:29 Saint Louis (STL) 1
AS 4221 Non-stop Boeing 737-800 (738) 1:44 Effective 2025-05-05 through 2025-05-12
Codeshare flight, operated by American Airlines.(AA 2303)
Mon,Tue,Sun 17:45 Fargo (FAR) 19:50 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:05 Effective 2025-11-30 through 2025-12-02
Codeshare flight, operated by American Airlines.(AA 3620)
Daily 18:36 Harrisburg (MDT) 19:50 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:14 Effective 2025-07-05 through 2025-08-05
Codeshare flight, operated by American Airlines.(AA 3719)
Sat 19:15 Philadelphia (PHL) F 21:07 Dayton (DAY)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:52 Valid until 2025-05-03
Codeshare flight, operated by American Airlines.(AA 5377)
Daily 20:00 Ronald Reagan Washington (DCA) 2 21:55 Cincinnati (CVG)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:55 Effective 2025-12-18 through 2026-01-05
Codeshare flight, operated by American Airlines.(AA 5673)
Daily 20:15 Austin (AUS) 21:27 Dallas Fort Worth (DFW)
AS 4221 Non-stop Boeing 737-800 (738) 1:12 Effective from 2026-02-12
Codeshare flight, operated by American Airlines.(AA 1661)
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This flight number is listed as serving the following routes:


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Alaska Airlines flight AS 4221: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Codeshare Flights:
Alaska Airlines AS4221
06:00
Austin (AUS)

08:47
Chicago O'Hare (ORD) 3
Effective 2025-05-10 through 2025-05-17
Mon
-
Tue
Wed
Thu
Fri
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 1064)
Duration: 2:47, non-stop
Boeing 737-800 (738)
Alaska Airlines AS4221
06:00
Austin (AUS)

08:47
Chicago O'Hare (ORD) 3
Effective 2025-05-18 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 1064)
Duration: 2:47, non-stop
Boeing 737-800 (738)
Alaska Airlines AS4221
06:01
Austin (AUS)

08:45
Chicago O'Hare (ORD) 3
Operates only on 2025-06-05
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 1064)
Duration: 2:44, non-stop
Airbus A319 (319)
Alaska Airlines AS4221
06:01
Austin (AUS)

08:50
Chicago O'Hare (ORD) 3
Effective 2025-06-06 through 2025-07-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 1064)
Duration: 2:49, non-stop
Boeing 737-800 (738)
Alaska Airlines AS4221
06:01
Austin (AUS)

08:48
Chicago O'Hare (ORD) 3
Operates only on 2025-07-03
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 1064)
Duration: 2:47, non-stop
Airbus A321 (321)
Alaska Airlines AS4221
07:27
Albany (ALB)

09:10
Chicago O'Hare (ORD) 3
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 3361)
Duration: 2:43, non-stop
Embraer EMB 170 / EMB 175 (E70)
Alaska Airlines AS4221
08:00
Chicago O'Hare (ORD) 3

10:06
Fort Wayne (FWA)
Effective 2025-11-08 through 2025-11-15
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 4905)
Duration: 1:06, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4221
08:00
Chicago O'Hare (ORD) 3

10:06
Fort Wayne (FWA)
Effective 2025-11-20 through 2025-11-22
Mon
-
Tue
-
Wed
-
Thu
Fri
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 4905)
Duration: 1:06, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4221
10:38
Chicago O'Hare (ORD) 3

12:55
Traverse City (TVC)
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 4948)
Duration: 1:17, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4221
10:41
Asheville/Hendersonville (AVL)

12:13
Ronald Reagan Washington (DCA) 2
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 4730)
Duration: 1:32, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4221
11:27
Harrisburg (MDT)

12:43
Chicago O'Hare (ORD) 3
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 3442)
Duration: 2:16, non-stop
Embraer EMB 170 / EMB 175 (E70)
Alaska Airlines AS4221
13:10
Chicago O'Hare (ORD) 3

16:10
Albany (ALB)
Effective 2025-11-02 through 2025-11-19
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 3414)
Duration: 2:00, non-stop
Embraer EMB 170 / EMB 175 (E70)
Alaska Airlines AS4221
14:50
Dallas Fort Worth (DFW) E

16:06
Lubbock (LBB)
Effective 2025-11-23 through 2025-11-28
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 6342)
Duration: 1:16, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4221
14:50
Chicago O'Hare (ORD) 3

17:49
Richmond (RIC)
Operates only on 2025-11-29
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 4896)
Duration: 1:59, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4221
14:50
Chicago O'Hare (ORD) 3

16:50
Fargo (FAR)
Effective 2025-11-30 through 2025-12-02
Mon
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 3620)
Duration: 2:00, non-stop
Embraer EMB 170 / EMB 175 (E70)
Alaska Airlines AS4221
16:16
Dayton (DAY)

17:55
Philadelphia (PHL) F
Effective 2025-10-06 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5874)
Duration: 1:39, non-stop
Embraer ERJ 145 (ER4)
Alaska Airlines AS4221
17:00
Ronald Reagan Washington (DCA) 2

18:56
Louisville (SDF)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5189)
Duration: 1:56, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4221
17:45
Dallas Fort Worth (DFW)

19:29
Saint Louis (STL) 1
Effective 2025-05-05 through 2025-05-12
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 2303)
Duration: 1:44, non-stop
Boeing 737-800 (738)
Alaska Airlines AS4221
17:45
Fargo (FAR)

19:50
Chicago O'Hare (ORD) 3
Effective 2025-11-30 through 2025-12-02
Mon
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 3620)
Duration: 2:05, non-stop
Embraer EMB 170 / EMB 175 (E70)
Alaska Airlines AS4221
18:36
Harrisburg (MDT)

19:50
Chicago O'Hare (ORD) 3
Effective 2025-07-05 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 3719)
Duration: 2:14, non-stop
Embraer EMB 170 / EMB 175 (E70)
Alaska Airlines AS4221
19:15
Philadelphia (PHL) F

21:07
Dayton (DAY)
Valid until 2025-05-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 5377)
Duration: 1:52, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4221
20:00
Ronald Reagan Washington (DCA) 2

21:55
Cincinnati (CVG)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5673)
Duration: 1:55, non-stop
Canadair CRJ 700 (CR7)
Alaska Airlines AS4221
20:15
Austin (AUS)

21:27
Dallas Fort Worth (DFW)
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 1661)
Duration: 1:12, non-stop
Boeing 737-800 (738)
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This flight number is listed as serving the following routes:
  • Asheville/Hendersonville (AVL) - Ronald Reagan Washington (DCA)
  • Austin (AUS) - Chicago O'Hare (ORD)
  • Austin (AUS) - Dallas Fort Worth (DFW)
  • Chicago O'Hare (ORD) - Albany (ALB)
  • Chicago O'Hare (ORD) - Fort Wayne (FWA)
  • Chicago O'Hare (ORD) - Richmond (RIC)
  • Chicago O'Hare (ORD) - Traverse City (TVC)
  • Dallas Fort Worth (DFW) - Lubbock (LBB)
  • Dallas Fort Worth (DFW) - Saint Louis (STL)
  • Fargo (FAR) - Chicago O'Hare (ORD)
  • Harrisburg (MDT) - Chicago O'Hare (ORD)
  • Philadelphia (PHL) - Dayton (DAY)
  • Ronald Reagan Washington (DCA) - Cincinnati (CVG)
  • Ronald Reagan Washington (DCA) - Louisville (SDF)
All Alaska Airlines flights
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